“School of Nano-Sciences”
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| Paper IPM / Nano-Sciences / 17469 |
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We study translocation of a flexible polymer chain through a membrane pore under the influence of active forces and steric exclusion using Langevin dynamics simulations within a minimal two-dimensional model. The active forces on the polymer are imparted by nonchiral and chiral active particles that are introduced on one side or both sides of a rigid membrane positioned across the midline of a confining box. We show that the polymer can translocate through the pore to either side of the dividing membrane in the absence of external forcing. Translocation of the polymer to a given side of the membrane is driven (hindered) by an effective pulling (pushing) exerted by the active particles that are present on that side. The effective pulling results from accumulation of active particles around the polymer. This crowding effect signifies persistent motion of active particles causing prolonged detention times for them close to the confining walls and the polymer. The effective pushing that hinders the translocation, on the other hand, results from steric collisions that occur between the polymer and active particles. As a result of the competition between these effective forces, we find a transition between two rectified cis-to-trans and trans-to-cis translocation regimes. This transition is identified by a sharp peak in the average translocation time. The effects of active particles on the transition is studied by analyzing how the translocation peak is regulated by the activity (self-propulsion) strength of these particles, their area fraction, and chirality strength.
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