“School of Biological Sciences”
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| Paper IPM / Biological Sciences / 17947 |
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| Abstract: | |||||||||
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Laser speckle contrast imaging (LSCI) is a non-invasive, powerful, and cost-efective imaging
technique that has seen widespread adoption across various medical felds, particularly for blood fow
imaging. While LSCI provides physicians with valuable insights into changes or occlusions in blood
fow, the technique is susceptible to various factors and parameters that can impact measurement
sensitivity and signal-to-noise ratio (SNR). These include the scattering of light, which can afect
the quality and reliability of the LSCI data. The polarization of light holds signifcant promise to
enhance the performance of LSCI. In this study, we employed polarization manipulation of light to
investigate its impact on the performance of LSCI for measuring fow. Focusing on the application
of LSCI in microcirculation within capillaries, we examined the efect of polarization control on
the techniqueâ??s fow measurement capabilities using a custom-designed phantom system. This
phantom consisted of three tubes with inner diameters of 1.1 mm, 1.6 mm, and 2.8 mm, embedded
in a polydimethylsiloxane (PDMS) matrix with optical properties similar to biological tissue. By
manipulating the polarization of both the incident and refected light, alternating between parallel
and perpendicular states, we compared the performance of our LSCI system in detecting fow for
diferent tube diameters and depths within the phantom. Our study revealed that while depth is
a critical parameter infuencing fow detection using LSCI, employing perpendicular polarization
(between incident and refected light) resulted in the lowest measurement error and highest SNR
compared to parallel polarization and the absence of polarization control.
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